- SELL / L-Selectin / CD62L Monoclonal Antibody
- LSBio
- Pricing InfoSupplier PageView Company Product Page
- LS-C43268
- Protein G purified
- CD62L, LAM1, LECAM1, LEU8, LNHR, LSEL, LYAM1, PLNHR, TQ1
- Flo, IHC, IHC-Fr, IHC-P, IP
- SELL / L-Selectin / CD62L
- Human
- IgG2b
- PBS, 0.09% Sodium Azide
- Unconjugated
- Mouse
- selectin L
- Monoclonal
- 0.1 mg
- FMC46
Specifications/Features
Specificity: Recognizes human CD62L, also known a L-selectin, a 74-95kD member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naÃ-ve lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation